Cayman Islands competed in the 2010 Commonwealth Games held in Delhi, India, from 3 to 14 October 2010. They won their first ever gold medal through Cydonie Mothersille in the 200m athletics for women.
Medalists
| Medal | Name | Sport | Event | Date |
|---|---|---|---|---|
| Gold | Cydonie Mothersill | Athletics | Women's 200m | October 12 |
Swimming
| Event | Swimmer(s) | Heats | Final | ||
|---|---|---|---|---|---|
| Result | Rank | Result | Rank | ||
| 200m Women's Freestyle | Tori Alden Flowers | 02:21.80 | 27 | DNQ | 27 |
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