| Rank | Series | Total worldwide box office | No. of films | Average of films | Highest-grossing film | |
| 1 | X-Men | $3,525,828,218 | 4 | $881,457,055 | Deadpool & Wolverine ($1,338,073,382) | | | Deadpool series | $2,906,806,782 | 3 | $968,935,594 | Deadpool & Wolverine ($1,338,073,382) | | 1 | Deadpool & Wolverine (2024) | $1,338,073,382 | | 2 | Deadpool 2 (2018) | $785,896,609 | | 3 | Deadpool (2016) | $782,836,791 | | | | Logan (2017) | $619,021,436 | | | |
| 2 | The Conjuring Universe † | $2,898,434,165 | 11 | $263,494,015 | Last Rites ($494,553,512) | | | The Conjuring series † | $1,344,211,430 | 4 | $336,052,858 | Last Rites ($494,553,512) | | 1 | Last Rites † (2025) | $494,553,512 | | 2 | The Conjuring 2 (2016) | $322,811,702 | | 3 | The Conjuring (2013) | $320,415,166 | | 4 | The Devil Made Me Do It (2021) | $206,431,050 | | | | Annabelle series | $795,434,744 | 3 | $265,144,915 | Creation ($306,592,201) | | 1 | Creation (2017) | $306,592,201 | | 2 | Annabelle (2014) | $257,589,952 | | 3 | Comes Home (2019) | $231,252,591 | | | | The Nun series | $635,549,870 | 2 | $317,774,935 | The Nun ($366,082,797) | | 1 | The Nun (2018) | $366,082,797 | | 2 | The Nun II (2023) | $269,467,073 | | | | The Curse of La Llorona (2019) | $123,233,739 | | | | | Wolves at the Door (2016) | $4,382 | | | |
| 3 | Alien | $1,995,371,782 | 9 | $221,707,976 | Prometheus ($403,354,469) | | | Main series | $1,687,653,807 | 7 | $241,093,401 | Prometheus ($403,354,469) | | 1 | Prometheus (2012) | $403,354,469 | | 2 | Romulus (2024) | $350,865,342 | | 3 | Covenant (2017) | $240,892,187 | | 4 | Alien (1979) | $188,034,787 | | 5 | Aliens (1986) | $183,316,455 | | 6 | Resurrection (1997) | $161,376,069 | | 7 | Alien 3 (1992) | $159,814,498 | | | | Alien vs. Predator | $307,717,975 | 2 | $153,858,988 | Alien vs. Predator ($177,427,090) | | 1 | Alien vs. Predator (2004) | $177,427,090 | | 2 | Requiem (2007) | $130,290,885 | | |
| 4 | The Matrix | $1,789,251,650 | 4 | $447,312,913 | The Matrix Reloaded ($741,847,937) | | 1 | Reloaded (2003) | $741,847,937 | | 2 | The Matrix (1999) | $463,517,383 | | 3 | Revolutions (2003) | $427,343,298 | | 4 | Resurrections (2021) | $156,543,032 | |
| 5 | The Hangover | $1,416,248,289 | 3 | $472,082,763 | The Hangover Part II ($586,764,305) | | 1 | The Hangover Part II (2011) | $586,764,305 | | 2 | The Hangover (2009) | $467,483,912 | | 3 | The Hangover Part III (2013) | $362,000,072 | |
| 6 | Demon Slayer: Kimetsu no Yaiba † | $1,412,597,994 | 4 | $353,149,499 | Infinity Castle ($789,900,000) | | 1 | Infinity Castle (2025) † | $789,900,000 | | 2 | Mugen Train (2020) | $512,704,063 | | 3 | To the Swordsmith Village (2023) | $59,554,259 | | 4 | To the Hashira Training (2024) | $50,439,672 | |
| 7 | Detective Chinatown | $1,356,285,654 | 3 | $452,095,218 | Detective Chinatown 3 ($686,257,563) | | 1 | Detective Chinatown 3 (2021) | $686,257,563 | | 2 | Detective Chinatown 2 (2018) | $544,185,156 | | 3 | Detective Chinatown (2016) | $125,842,935 | |
| 8 | Fifty Shades | $1,322,263,368 | 3 | $440,754,456 | Grey ($568,810,483) | | 1 | Grey (2015) | $568,810,483 | | 2 | Darker (2017) | $381,543,436 | | 3 | Freed (2018) | $371,909,449 | |
| 9 | Terminator | $1,292,704,949 | 4 | $323,176,237 | Judgment Day ($519,843,345) | | 1 | Judgment Day (1991) | $519,843,345 | | 2 | Rise of the Machines (2003) | $433,371,112 | | 3 | Dark Fate (2019) | $261,119,292 | | 4 | The Terminator (1984) | $78,371,200 | |
| 10 | Joker | $1,285,216,627 | 3 | $428,405,542 | Joker ($1,074,354,306) | | 1 | Joker (2019) | $1,074,354,306 | | 2 | Joker: Folie à Deux (2024) | $206,400,287 | | 3 | The Killing Joke (2016) | $4,462,034 | |
| 11 | Resident Evil | $1,284,423,262 | 11 | $116,765,751 | The Final Chapter ($314,101,190) | | | Original series | $1,237,978,176 | 6 | $206,329,696 | The Final Chapter ($314,101,190) | | 1 | The Final Chapter (2017) | $314,101,190 | | 2 | Afterlife (2010) | $300,228,084 | | 3 | Retribution (2012) | $240,647,629 | | 4 | Extinction (2007) | $149,871,103 | | 5 | Apocalypse (2004) | $129,342,769 | | 6 | Resident Evil (2002) | $103,787,401 | | | | Animated series | $4,530,171 | 4 | $1,132,543 | Damnation ($2,325,035) | | 1 | Damnation (2012) | $2,325,035 | | 2 | Vendetta (2017) | $1,623,063 | | 3 | Degeneration (2008) | $538,912 | | 4 | Death Island (2023) | $43,161 | | | | Welcome to Raccoon City (2021) | $41,914,915 | | | |
| 12 | Bad Boys | $1,243,628,584 | 4 | $310,907,146 | For Life ($425,514,702) | | 1 | For Life (2020) | $425,514,702 | | 2 | Ride or Die (2024) | $403,367,302 | | 3 | Bad Boys II (2003) | $273,339,556 | | 4 | Bad Boys (1995) | $141,407,024 | |
| 13 | It | $1,177,366,042 | 2 | $588,683,021 | It ($704,242,888) | | 1 | It (2017) | $704,242,888 | | 2 | It Chapter Two (2019) | $473,123,154 | |
| 14 | John Wick | $1,166,143,148 | 5 | $233,228,630 | John Wick: Chapter 4 ($440,146,694) | | | Main Series | $1,028,926,563 | 4 | $257,231,641 | John Wick: Chapter 4 ($440,146,694) | | 1 | Chapter 4 (2023) | $440,146,694 | | 2 | Chapter 3 – Parabellum (2019) | $328,349,387 | | 3 | Chapter 2 (2017) | $174,348,632 | | 4 | John Wick (2014) | $86,081,850 | | | | Ballerina (2025) | $137,216,585 | | | |
| 15 | Saw | $1,128,720,386 | 10 | $112,872,039 | Saw III ($164,874,275) | | 1 | Saw III (2006) | $164,874,275 | | 2 | Saw II (2005) | $147,748,505 | | 3 | Saw IV (2007) | $139,352,633 | | 4 | Saw 3D (2010) | $136,150,434 | | 5 | Saw V (2008) | $113,864,059 | | 6 | Saw X (2023) | $111,828,698 | | 7 | Saw (2004) | $103,096,345 | | 8 | Jigsaw (2017) | $102,952,888 | | 9 | Saw VI (2009) | $68,233,629 | | 10 | Spiral (2021) | $40,618,920 | |
| 16 | Die Hard | $1,052,554,898 | 4 | $263,138,725 | Die Hard with a Vengeance ($366,101,666) | | 1 | Die Hard with a Vengeance (1995) | $366,101,666 | | 2 | A Good Day to Die Hard (2013) | $304,654,182 | | 3 | Die Hard 2 (1990) | $241,031,094 | | 4 | Die Hard (1988) | $140,767,956 | |
| 17 | American Pie | $989,475,386 | 4 | $247,368,847 | American Pie 2 ($287,553,595) | | 1 | American Pie 2 (2001) | $287,553,595 | | 2 | American Pie (1999) | $235,483,004 | | 3 | American Reunion (2012) | $234,989,584 | | 4 | American Wedding (2003) | $231,449,203 | |
| 18 | Final Destination | $983,714,779 | 6 | $163,952,463 | Bloodlines ($315,730,814) | | 1 | Bloodlines (2025) | $315,730,814 | | 2 | The Final Destination (2009) | $187,384,627 | | 3 | Final Destination 5 (2011) | $157,887,643 | | 4 | Final Destination 3 (2006) | $118,890,272 | | 5 | Final Destination (2000) | $112,880,294 | | 6 | Final Destination 2 (2003) | $90,941,129 | |
| 19 | Gladiator | $927,696,965 | 2 | $463,848,483 | Gladiator ($465,516,248) | | 1 | Gladiator (2000) | $465,516,248 | | 2 | Gladiator II (2024) | $462,180,717 | |
| 20 | Hannibal | $927,409,175 | 5 | $185,481,835 | Hannibal ($351,692,268) | | 1 | Hannibal (2001) | $351,692,268 | | 2 | The Silence of the Lambs (1991) | $275,726,716 | | 3 | Red Dragon (2002) | $209,196,298 | | 4 | Hannibal Rising (2007) | $82,169,884 | | 5 | Manhunter (1986) | $8,624,009 | |